Our results confirm the outstanding impact of the classical risk factors on myocardial infarction and total mortality in a southern German population. As a consequence, the Wenckebach point during high rate atrial pacing was significantly lowered by Verapamil and D 600, but only insignificantly by Ro 11-1781. The overall extent of arteriosclerotic lesions of each artery was classified to one of the following 4 degrees of intimal involvement 0-25, 26-50, 51-75%, 76-100%. If we limit the analysis to only the histologically proven cases, our data suggest a specificity of the method of 86% and a sensitivity of about 67%. The metabolic changes suggest a marked sensitivity to ischemia as well as prolonged postischemic abnormalities of cardiac fatty acid metabolism in jeopardized myocardium. Between November 1992 and June 1995, we performed 1000 dobutamine stress echocardiographies. In the placebo group, one patient underwent acute cardiac transplantation due to rapid clinical deterioration; another patient died suddenly after 5 months.
A heart-to-lung ratio of 1. At baseline, 1074 men and 1013 women aged 45-64 years were randomly selected from the population in the Augsburg region and extensively interviewed and examined regarding their cardiovascular risk profile. Two and twelve hours after acute medication working capacity increased to 220% and 139% respectively. The genetic pattern is autosomal dominant with variable expressivity. All the hemodynamic chances were most pronounced in a group with left ventricular aneurysm. Symposium on Fibrinolytic Therapy, Bonn, April 1982, abstracts, no. Comparing postmortem and intravital extent of arteriosclerotic lesions some peculiarities of postmortem specimens should be considered.
The scans were correlated with the clinical course, and in 20 cases with the results from histologic examination of the valves. Homogeneous postexercise uptake was followed by decreasing segmental activity in 75. In comparison to placebo, no proarrhythmogenic effect of pimobendan was detected. On the first 2 days, all volunteers received a double amount of tablets for digoxin loading. Hemodynamics measures and indices of myocardial contractility were determined in 110 patients with coronary heart disease. Twenty-one patients 3 women, 18 males, mean age 55. When comparing the 4 different vascular regions of each patient we found maximal deviations by 1 degree in 34%, by 2 degrees in 41% and by 3 degrees in 20%.
It is concluded that the In-111 method has a high sensitivity and specificity in detecting heart transplant rejection and may be useful in the monitoring of patients in the chronic phase after heart transplantation. In one patient sustained ventricular tachycardia developed and progressed towards ventricular fibrillation. Bicycle ergometry was performed before, 2, 6 and 12 h after medication and nitrate plasma levels were drawn before each exercise test. This patient underwent epicardial lead implantation 1 day later. Dobutamine stress echocardiography has proven to be a safe and feasible method in the diagnosis of coronary heart disease. Two patients died on placebo, whereas no patient expired on verum. The mean digoxin serum concentrations were 0.
After one week of therapy the same parameters were measured to look for the development of tolerance. Considerable intraindividual differences are the rule and a severe, generalized uniform affection is an exception. All three Ca-antagonists caused a slight shortening of the cycle length which was only significant after verapamil. Coronary reserve was lower in transplant recipients than in normal controls 2. Five out of 12 patients showed an increase of the effective recovery period. The results demonstrated decreased left ventricular compliance in coronary heart disease. The rate advancement periods for myocardial infarction related to treated hypertension, hypercholesterolemia and heavy smoking were 10.
During 60 min the initial heart rate before application of the drug was not yet reached again. Systemic vascular resistance was reduced p less than 0. Non-cardiac side effects were found in 5 patients. Weiterhin veröffentlicht die Zeitschrift Klinische Übersichten nach dem neuesten Stand zusammengefaßte Darstellungen aus den Bereichen Kardiologie Angiologie sowie Herz- und Gefäßchirurgie Fortschritte der Forschung zusammenfassende Darstellungen aus den Bereichen experimentelle Medizin Pharmakologie Physiologie und Pathologie Berichte über neue Herz-Kreislauf-Pharmaka sowie neue diagnostische Methoden und Geräte und Tagungsberichte. In six cases the scintigraphic examination gave correct positive results, in three cases false negative, in one case a false positive, and in 20 cases correct negative results. The benefit derived from this treatment considerably exceeds the risk; thus, there is no need for additional studies. In conclusion, the results of this study show that a positive digitalis effect is demonstrable following the relatively small dose of beta-methyl digoxin 0.
Regarding the extent of arteriosclerosis there are artery- and additional localization-specific features. It is concluded that Ro 11-1781 prolongs av nodal conduction and may be of therapeutic value in the treatment of supraventricular arrhythmias. In the first part of the investigation, systolic time intervals were determined as an indicator of left ventricular performance in 10 patients without cardiac disease before and 5 min after i. Verhandlungen der Deutschen Gesellschaft für Herz- und Kreislaufforschung, vol 47. The remaining 88 showed complicated lesions in at least 1 vascular region. The results seem to demonstrate a primary or secondary involvement of the sympathetic nervous system in these entities of hitherto unknown etiology.
After two antegrade balloon-dilatations the pressure gradient over the stenotic aortic valve was reduced from 80 mmHg to 15 mmHg. Atropine was given additionally in 440 patients, with a mean dose of 0. Clinical symptoms were not altered; six patients two in each group died suddenly. This 12-h benefit is 40% od the maximum effect. More than 99% of left ventricular segment of controls showed homogeneous tracer uptake and release, indicating homogeneous free fatty acid turnover in normal myocardium.